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KMID : 0350519920450010337
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Journal of Catholic Medical College
1992 Volume.45 No. 1 p.337 ~ p.345
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8MHz Radiofrequency-Capacitive Heating on Rabbit Lung
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Abstract
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Hyperthermia has attrected considerable attention recently as an additional modality in cancer treatment. Despite much research work over the past decade, it is difficult to heat tumors in the thorax. The difficulties in applying hyperthermia to
the
lung relate to the physical difficulties associated with the delivery of heat. When localized hyperthermia is achieved by radiofrequency(RF)-in duced currents,the prescence of bone or air causes distortions of the heating pattern.
The purpose of present investigation was to assess the heat effect on rabbit lung comparing with rabbit liver as solid organ using RF heating machine.
In this study, 20 rabbits were divided into 2 groups according to the heating sites and the methods of temperature measurement; in group I(10); lung heating and temperature measuring on skin, esophagus and lung parenchyme; in group II(10) ; liver
heating and temperature measuring on skin and liver parenchyme.
@ES The results were as follows;
@EN 1. In the lung heating group, the mean temperature was 41*1.7℃ in lung, 42*1.7℃ in esophagus, and 37.8*1.5℃ on skin, respectively.
2. In the liver heating group, the mean temperature of liver was 42.1*1.6℃,and the mean temperature of skin was 39.5*1.4℃.
3. The time required to reach 42℃ was 9.3*1.8 min in the lung heating group,and 5.7*0.7 min in the liver heating group.
4. The temperature increasing rate was 0.46*0.17℃/min in the lung heating group, and 0.56*0.2℃/min in the liver heating group.
5. The mean RF power required to reach 42-43℃ was 48*20 W in the lung heating group,and 39*19 W in the liver heating group respectively, thus higher RF power was required in the lung heating than in the liver heating(P<0.05).
6. The mean temperature of esophagus was 1.1*0.9℃, and higher than that of lung parenchyme(P<0.05)
Therefore, it is concluded that lung as air containing organ is properly heated as well as liver as solid organ. Thus more active trials of lung heating in the lung cancer must be likely considered. However when the lung is heated, the
mediastinum
demage must be considered seriously because the esophageal temperature is higer than the lung parenchyme.
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